Dickkopf-1 promotes hematopoietic regeneration via direct and niche-mediated mechanisms
نویسندگان
چکیده
منابع مشابه
Fish Oil-Rich Diet Promotes Hematopoiesis and Alters Hematopoietic Niche.
The self-renewal and differentiation of hematopoietic stem cells (HSCs) in bone marrow are essential to replenish all blood cell types, but how this process is influenced by diet remains largely unclear. Here we show that a diet rich in fish oils promotes self-renewal of HSCs and extramedullary hematopoiesis. Chronic intake of a fish oil-rich diet increases the abundance of HSCs, alters the hem...
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Hematopoietic stem cells (HSCs) are maintained by a perivascular niche in bone marrow but it is unclear whether the niche is reciprocally regulated by HSCs. Here, we systematically assessed the expression and function of Angiopoietin-1 (Angpt1) in bone marrow. Angpt1 was not expressed by osteoblasts. Angpt1 was most highly expressed by HSCs, and at lower levels by c-kit(+) hematopoietic progeni...
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BACKGROUND Various clinical reports suggest etanercept (ETN) has some efficacy in bone formation in rheumatoid arthritis (RA). To examine this effect, we investigated the gene expression of cytokines relevant to osteoblast/osteoclast differentiation, and evaluated histomorphometric findings in mature rats with collagen-induced arthritis (CIA). METHODS Total RNA was extracted from knee joints ...
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Department of Molecular & Human Genetics, Baylor College of Medicine, Houston, TX 77030, 9 USA 10 Graduate Program in Translational Biology and Molecular Medicine, Baylor College of 11 Medicine, Houston, TX 77030, USA 12 Division of Hematology/Oncology, Department of Medicine, University of Michigan, Ann Arbor, 13 MI 48109, USA 14 Division of Cell Medicine, Department of Life Science, Medical R...
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ژورنال
عنوان ژورنال: Nature Medicine
سال: 2016
ISSN: 1078-8956,1546-170X
DOI: 10.1038/nm.4251